Hydrochloric Acid → HCID 178491620, compound

Participants

Reaction Steps

To an ice cold solution of 5-mercapto-1H-tetrazole-1-acetic acid (4.4 g) in N,N-dimethylformamide (40 ml) is added N,N'-carbonyldiimidazole (4.86 g), and the mixture is stirred under nitrogen for 1 hour. To this solution is added a solution of p-methoxybenzyloxyamine (7.9 g) in N,N-dimethylformamide (10 ml), and the mixture is stirred under ice cooling for 45 minutes. The reaction mixture is poured onto ice water containing hydrochloric acid and extracted with ethyl acetate. The extract solution is washed with water, dried and concentrated under reduced pressure. The residue is crystallized from a mixture of acetone and ether to give the title compound (7.3 g). mp. 167°-168° C.

Provenance & Evidence