HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 6-Chloro-2-[(4-ethoxyphenyl)amino]-3-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | 4-Ethoxyaniline | HCID 9076 | — |
| Reactant | 2,6-Dichloro-3-nitrobenzoic acid | HCID 350623 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-Chloro-2-[(4-ethoxyphenyl)amino]-3-nitrobenzoic acid | HCID 13753447 | — |
Reaction Steps
A mixture of 28.0 g of p-phenetidine, 23.6 g of 2,6-dichloro-3-nitrobenzoic acid, and 80 ml of N,N-dimethylaniline was heated five hours on a steam bath. The resulting mixture was diluted with chloroform and extracted with 1N sodium hydroxide. Acidification of the aqueous extract yielded 6-chloro-2-[(4-ethoxyphenyl)amino]-3-nitrobenzoic acid as reddish brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04555572 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-ce955f3f849c40a1954ed8e1231312a0 |
| Source note | uspto-grants-1985_11 |