Nitric Acid → 4-Methyl-3-nitrobenzonitrile

Participants

Reaction Steps

399 g (2.56 mol) of 4-methylbenzonitrile were added over the course of 90 min into 1 l of fuming nitric acid at -10° C. 1 h after the addition, the mixture was poured into 2.5 l of ice-water, whereupon a solid precipitated and was separated off on a suction filter funnel and washed to neutral pH with water. The yield was 363 g (88%). 1H-NMR (CDCl3 ; δ in ppm): 8.3 (d,1H); 7.8 (dd, 1H); 7.5 (dd, 1H); 2.7 (s, 3H)

Provenance & Evidence