Potassium Carbonate → 4-[[(Diphenylmethylene)amino]methyl]benzonitrile

Participants

Reaction Steps

270 g (2.0 mol) of anhydrous K2CO3 were added to a solution of 150 g (0.8 mol) of 97% pure benzophenone imine and 144.8 g (0.74 mol) of p-cyanobenzyl bromide in 450 ml of acetonitrile, and the mixture was left to stir at room temperature for 6 h. The inorganic salts were filtered off with suction and then most of the solvent was removed by distillation, 300 ml of water were added to the residue, and the mixture was extracted several times with ethyl acetate. The organic phase was washed 2× with water, dried over Na2SO4 and evaporated to dryness. Digestion with ether resulted in 180 g of white crystals, melting point 101-102° C.

Provenance & Evidence