4,5-Dichlorophthalic anhydride → 5,6-dichloro-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-isoindole-1,3(2H)-dione

HRID 15841Notes

Reaction equation

HRID 15841 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=3)[NH2:23])[CH2:14][CH2:13]2)[N:3]=1.[Cl:27][C:28]1[C:38]([Cl:39])=[CH:37][C:31]2[C:32](=O)[O:33][C:34](=[O:35])[C:30]=2[CH:29]=1>>[Cl:27][C:28]1[CH:29]=[C:30]2[C:31](=[CH:37][C:38]=1[Cl:39])[C:32](=[O:33])[N:23]([C:22]1[CH:24]=[CH:25][CH:26]=[C:20]([CH2:19][CH2:18][N:15]3[CH2:14][CH2:13][N:12]([C:8]4[CH:7]=[CH:6][CH:5]=[C:4]5[C:9]=4[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]5)[CH2:17][CH2:16]3)[CH:21]=1)[C:34]2=[O:35]

Participants

3

Reactant 2

HCID 703344,5-Dichlorophthalic anhydrideHCID 498521053-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

Product 1

HCID 684256685,6-dichloro-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-isoindole-1,3(2H)-dione

Procedure

Prepared from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 5,6-dichloro-2-benzofuran-1,3-dione according to Method I.

Sources & evidence

ORD record
ord-d34bbbeaa73343779da328a2872d654b
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Reaction notes

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