反应详情

Using an analogous procedure to that described in Example 1, 4-(3'-chloro-4'-fluoroanilino)-6-hydroxyquinazoline was reacted with 3-dimethylaminopropyl chloride hydrochloride to give 4-(3'-chloro-4'-fluoroanilino)-6-(3-dimethylaminopropoxy)quinazoline in 72% yield; NMR Spectrum: 1.98 (m, 2H), 2.34 (s, 6H), 2.51 (t, 2H), 4.22 (t, 2H), 7.48 (t, 1H), 7.52 (m, 1H), 7.75 (d, 1H), 7.85 (m, 1H), 7.91 (m, 1H), 8.18 (m, 1H), 8.54 (s, 1H), 9.72 (broad s, 1H); Elemental Analysis: Found C, 60.5; H, 5.3; N, 14.9; C19H20ClFN4O requires C, 60.5l; H, 5.3; N, 14.9%.