Sodium Hydroxide → 1-(2-Methoxyphenyl)piperazine

HRID 1584118Notes

Reaction equation

HRID 1584118 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[OH-].[Na+]>C(Cl)(Cl)Cl>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9899402N-(2-Methoxyphenyl)piperazine hydrochloride

Product 1

HCID 13461-(2-Methoxyphenyl)piperazineYield 95.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The mixture of 1-(2-methoxyphenyl) piperazine hydrochloride (6.86 g, 30 mmol), aq. NaOH (2.5N, 36 mL, 90 mmol) and chloroform (30 mL) was vigorously stirred for 0.5 h. Chloroform layer was separated and stirred with water (50 mL) for another 0.5 h. Chloroform layer after separation was filtrated through Na2SO4 (2 g) and evaporated in vacuo to dryness. The oil residue was dried in vacuo (2 mm Hg, 1 h, 80° C.) to give 5.50 g (95%) of 4-(2-methoxyphenyl)piperazine as slightly yellow oil. It was used in synthesises without further purification.

Workup

  1. customChloroform layer was separated
  2. stirringstirred with water (50 mL) for another 0.5 h
  3. customChloroform layer after separation
  4. filtrationwas filtrated through Na2SO4 (2 g)
  5. customevaporated in vacuo to dryness
  6. customThe oil residue was dried in vacuo (2 mm Hg, 1 h, 80° C.)

Sources & evidence

ORD record
ord-4814d4081d7b4fd393ba632cb698f7fe
Source dataset
uspto-grants-1999_08
Patent number
US05932584

Reaction notes

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