反应详情

A mixture of 4-(1-imidazolyl)butyric acid benzyl ester (7.4 g), 5% palladium-carbon (1.0 g) and ethanol (400 ml) was catalytically reduced at room temperature under 1 atm. After the catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the residual crystal was recrystallized from ethanol, to yield 4-(1-imidazolyl)butyric acid (3.4 g, 75%) as a colorless prismatic crystal having a melting point of 125 to 126° C.

1. customwas catalytically reduced at room temperature under 1 atm
2. filtrationAfter the catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customthe residual crystal was recrystallized from ethanol