HCID 131721327, compound → HCID 131721329, compound

Participants

Reaction Steps

A solution of Boc-D-3,3-diphenylalanine-L-proline-N-(trans-4-imidazoleallyl) amide (55 mg, 0.1 mmol) in 2:1 methylene chloride/TFA (30 ml) was stirred at room temperature for 4 h. The solvents were removed in vacuo and the residue was purified by preparative HPLC. 1H NMR (CH3OD) d 1.10-1.37 (m, 2 H), 1.70-1.90 (br s, 2 H), 2.70-2.90 (br m, 1 H), 3.50-3.65 (br m, 1 H) 3.95 (br s, 2 H), 4.00-4.10 (br m, 1 H), 4.45 (d, J=11.5 Hz, 1 H), 4.95 (d, J=11.5 Hz, 1 H) 6.30-6.40 (m, 1 H), 6.58 (d, J=16 Hz, 1 H), 7.25-7.70 (m, 11 H), 7.85 (s, 1 H); MS (FAB) 444 (M+1)+.

Provenance & Evidence