HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1584272Generated: November 4, 2026
Trifluoroacetic acid → 1,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide trifluoroacetate
https://huagongshe.com/reaction/1584272
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(t-Butyloxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide | HCID 70103220 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide trifluoroacetate | HCID 70120572 | — |
Reaction Steps
To a solution of 2-(t-butyloxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide (1.18 g, 2.4 mmol) in CH2Cl2 (6 mL) was added CF3CO2H (4 mL). The reaction was stirred for 0.75 hr at 25° C. Evaporation in vacuo yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05932590 |
|---|
| Source dataset | uspto-grants-1999_08 |
|---|
| ORD ID | ord-e1d8def29340493fa1ad11cadf6c2903 |
|---|
| Source note | uspto-grants-1999_08 |
|---|
