HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazole, 4-(chloromethyl)-5-methyl-2-phenyl- → 5-[3-[3-Methoxy-4-(5-methyl-2-phenyl-4-thiazolylmethoxy]phenyl]propyl]-2,4-oxazolidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazole, 4-(chloromethyl)-5-methyl-2-phenyl- | HCID 12794636 | — |
| Reactant | 5-[3-(4-Hydroxy-3-methoxyphenyl)propyl]-2,4-oxazolidinedione | HCID 69830471 | — |
| Product | 5-[3-[3-Methoxy-4-(5-methyl-2-phenyl-4-thiazolylmethoxy]phenyl]propyl]-2,4-oxazolidinedione | HCID 21224446 | — |
Reaction Steps
In substantially the same manner as in Working Example 9, 5-[3-(4-hydroxy-3-methoxyphenyl)propyl]-2,4-oxazolidinedione was reacted with 4-chloromethyl-5-methyl-2-phenylthiazole to obtain 5-[3-[3-methoxy-4-(5-methyl-2-phenyl-4-thiazolylmethoxy]phenyl]propyl]-2,4-oxazolidinedione, which was recrystallized from ethyl acetate-chloroform to give colorless prisms, m.p.128-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05932601 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-92e67c0ad4a1460b8fd171b17a2526ca |
| Source note | uspto-grants-1999_08 |