Isovanillin → HCID 21224416, compound

HRID 1584346Notes

Reaction equation

HRID 1584346 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8].[O:15]=[CH:16][C:17]1[CH:25]=[CH:24][C:21]([O:22][CH3:23])=[C:19]([OH:20])[CH:18]=1>>[CH3:23][O:22][C:21]1[CH:24]=[CH:25][C:17]([CH:16]=[O:15])=[CH:18][C:19]=1[O:20][CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 12127IsovanillinHCID 97942894-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole

Product 1

HCID 21224416HCID 21224416, compound

Procedure

In substantially the same manner as in Reference Example 3, 4-chloromethyl-5-methyl-2-phenyloxazole was allowed to react with isovanilline to yield 4-methoxy-3-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde, which was recrystallized from ethyl acetate-hexane to give colorless prisms, m.p.121-122° C.

Sources & evidence

ORD record
ord-9cd65158f4cf401080d216415198dcff
Source dataset
uspto-grants-1999_08
Patent number
US05932601

Reaction notes

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