Trimethyl phosphonoacetate → HCID 54560603, compound

HRID 1584347Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][C:4]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][C:17]=1[CH3:18].[CH3:25][O:26][C:27]([CH2:29]P(OC)(OC)=O)=[O:28]>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[CH:29][C:27]([O:26][CH3:25])=[O:28])=[CH:5][C:4]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][C:17]=1[CH3:18]

Participants

Reactant 2

HCID 80029Trimethyl phosphonoacetate

HCID 21224416HCID 21224416, compound

Product 1

HCID 54560603HCID 54560603, compound

Procedure

In substantially the same manner as in Reference Example 16, 4-methoxy-3-(5-methyl-2-phenyl-4-oxazolyl methoxy)benzaldehyde was allowed to react with trimethyl phosphonoacetate to yield methyl 4-methoxy-3-(5-methyl-2-phenyl-4-oxazolylmethoxy)cinnamate, which was recrystallized from ethyl acetate-ether to give colorless needles, m.p.135-136° C.

Sources & evidence

ORD record: ord-29d4fac6d6ff41628b982e7e6c5577a4
Source dataset: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05932601

Reaction notes

Loading…