Methanol → HCID 10936832, compound

Participants

Reaction Steps

To a mixture of ethyl 3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]propionate (20 g), sodium borohydride (9.8 g) and tetrahydrofuran (THF) (200 ml) was added dropwise methanol (50 ml) over 2 hours under reflux. The reaction mixture was poured into water, which was subjected to extraction with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4) and concentrated to yield 3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]propanol (15.5 g, 87%), which was recrystallized from ethyl acetate-hexane to give colorless prisms, m.p.99-100° C.

Provenance & Evidence