Water → HCID 10916695, compound

Participants

Reaction Steps

Isopropyl (S)-(-)-5-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]-2-hydroxypentanoate (3.55 g) was dissolved in methanolic HCl (5%, 100 ml). The solution was stirred for 10 hours at room temperature, which was poured into water, followed by extraction with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4) and concentrated. The residue was subjected to column chromatography on silica gel. From the fraction eluted with ethyl acetate-hexane (1:1), was obtained methyl (S)-(+)-5-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]-2-hydroxypentanoate (3.03 g, 91%). Recrystallization from ethyl acetate-hexane gave colorless prisms, m.p.80-81° C. [α]D +3.03° (c=1. 0, CHCl3)

Provenance & Evidence