Benzyl Bromide → HCID 21224436, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 5-(4-hydroxy-3-methoxyphenyl)pentanoate (27.92 g), benzyl bromide (20.82 g), potassium carbonate (22.9 g) and N,N-dimethylformamide (DMF) (140 ml) was stirred for 15 hours at 90° C. The reaction mixture was concentrated under reduced pressure. The residue was subjected to column chromatography on silica gel. From the fraction eluted with ethyl acetate-hexane (1:6, v/v), was obtained ethyl 5-(4-benzyloxy-3-methoxyphenyl)pentanoate (31.64 g, 84%),

Provenance & Evidence