HCID 86754371, compound → HCID 21224176, compound

Participants

Reaction Steps

Following the procedure outlined in Example 15A, N-hydroxy-2-[4-(4-phenoxyphenylsulfonyl)-cyclohexanone-4-yl]-acetamide ethylene ketal (400 mg) was prepared from the corresponding N-tert-butoxy precursor. The above product was dissolved in a 1:1 mixture of acetone and 1M hydrochloric acid (40 ml) and stirred at room temperature for 18 hours. The reaction was concentrated under reduced pressure and extracted with ethyl acetate. Silica gel chromatography using 10% methanol/methylene chloride gave 2-[4-(4-phenoxyphenylsulfonyl)cyclohexanone-4-yl]-N-hydroxyacetamide as a white solid: m.p. 106° C. (dec), m/e=404 (MH+, FABMS).

Provenance & Evidence