HCID 21224130, compound → HCID 54441420, compound

Participants

Reaction Conditions

Reaction Steps

Thiophenol (80 mg) was stirred for 45 min with potassium hydride (40 mg) in N,N-dimethylformamide (1 ml) to produce a homogeneous solution of potassium thiophenolate. To this mixture was added 3-benzyl-3-(4-bromophenylsulfonyl)-propionic acid (100 mg) dissolved in N,N-dimethylformamide (1 ml) at room temperature. After stirring for 16 hours at 75° C. the mixture was partitioned between aqueous citric acid and water, giving a product which was purified by preparative TLC to afford 3-benzyl-3-(4-phenylthiophenylsulfonyl)-propionic acid (30 mg).

Provenance & Evidence