Hydrochloric Acid → HCID 21224234, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 20A, N-tert-butoxy-2-[4-(4-phenoxyphenylsulfonyl)-1-(ethoxycarbonylmethyl)piperidin-4-yl]-acetamide, was dissolved in dichloroethane (10 ml), cooled to 0° C., and saturated with hydrochloric acid gas. The reaction vessel was then sealed and the solution stirred for two days at 25° C. Solvent was removed from the reaction mixture under reduced pressure, and the residue purified by preparative TLC, eluting with 10% methanol/methylene chloride, to give N-hydroxy-2-[4-(4-phenoxyphenylsulfonyl)-1-(ethoxycarbonylmethyl)piperidin-4-yl]-acetamide (420 mg), m/e=477.1 (MH+, FABMS).

Provenance & Evidence