HCID 10881318, compound → HCID 21224995, compound

HRID 1584573Notes

Reaction equation

HRID 1584573 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]=2[NH:18]C(=O)C(F)(F)F)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)S(O[C:31]1[CH2:36][CH2:35][CH:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH2:33][CH:32]=1)(=O)=O>>[C:1]1([C:7]2[NH:18][C:10]3[C:9]([C:8]=2[C:31]2[CH2:36][CH2:35][CH:34]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[CH2:33][CH:32]=2)=[CH:17][CH:16]=[C:12]([C:13]([OH:15])=[O:14])[CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 10881318HCID 10881318, compoundHCID 21225014HCID 21225014, compound

Product 1

HCID 21224995HCID 21224995, compound

Procedure

The title compound was prepared according to the procedure outlined in Example 7, employing 4-(2-phenylacetylenyl)-3-trifluoroacetamidobenzoic acid on Wang resin (prepared according to Example 3) and 4-phenylcyclohex-1-enyl trifluoromethanesulfonate; 1H NMR (DMSO-d6) δ 1.90 (m, 2 H), 2.40 (m, 3 H), 3.00 (m, 1 H), 5.90 (m, 1 H), 7.20 (m, 1 H), 7.30 (m, 5 H), 7.50 (m, 2 H), 7.75 (m, 5 H), 7.95 (m, 1 H), 11.60 (s, 1 H).

Sources & evidence

ORD record
ord-a4d4f3b837374cfab821abc03b1bdf07
Source dataset
uspto-grants-1999_08
Patent number
US05932743

Reaction notes

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