HCID 10892194, compound → HCID 15434604, compound

HRID 1584574Notes

Reaction equation

HRID 1584574 reaction equation
[C:1]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[NH:16]C(=O)C(F)(F)F)#[C:2][CH2:3][CH2:4][CH2:5][CH3:6].FC(F)(F)S(O[C:29]1[C:38]2[C:33](=[C:34]([O:39][CH3:40])[CH:35]=[CH:36][CH:37]=2)[CH2:32][CH2:31][CH:30]=1)(=O)=O>>[CH2:3]([C:2]1[NH:16][C:8]2[C:7]([C:1]=1[C:29]1[C:38]3[C:33](=[C:34]([O:39][CH3:40])[CH:35]=[CH:36][CH:37]=3)[CH2:32][CH2:31][CH:30]=1)=[CH:15][CH:14]=[C:10]([C:11]([OH:13])=[O:12])[CH:9]=2)[CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 10892194HCID 10892194, compoundHCID 21224993HCID 21224993, compound

Product 1

HCID 15434604HCID 15434604, compound

Procedure

The title compound was prepared according to the procedure outlined in Example 7, employing 4-(1-hexynyl)-3-trifluoroacetamidobenzoic acid on Wang resin (prepared according to Example 1) and 5-methoxy-3,4-dihydro-naphthalen-1-yl trifluoromethanesulfonate; 1H NMR (DMSO-d6) δ 0.80 (t, 3 H), 1.22 (m, 2 H), 1.60 (m, 2 H), 2.39 (m, 2 H), 2.70 (m, 4 H), 3.80 (s, 3 H), 6.02 (t, 1 H), 6.32 (d, 1 H), 6.85 (d, 1 H), 6.98 (m, 1 H), 7.08 (d, 1 H), 7.50 (d, 1 H), 7.95 (s, 1 H), 11.40 (s, 1 H).

Sources & evidence

ORD record
ord-64a195d91f9544c69609a1624a054d57
Source dataset
uspto-grants-1999_08
Patent number
US05932743

Reaction notes

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