Acetic Acid → HCID 21224836, compound

HRID 1584586Notes

Reaction equation

HRID 1584586 reaction equation
[Cl:1][C:2]1[C:3]([CH2:11][N:12]2C(C=O)=[C:15]([S:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[N:14]=[C:13]2[S:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=2)=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.[CH2:39](Cl)Cl.CO.[C-]#N.[Na+].[C:47]([OH:50])(=[O:49])[CH3:48]>[O-2].[Mn+2]>[CH3:39][O:49][C:47]([C:48]1[N:12]([CH2:11][C:3]2[C:2]([Cl:1])=[CH:10][C:6]3[O:7][CH2:8][O:9][C:5]=3[CH:4]=2)[C:13]([S:29][CH2:30][C:31]2[CH:32]=[CH:33][C:34]([O:37][CH3:38])=[CH:35][CH:36]=2)=[N:14][C:15]=1[S:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)=[O:50]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 8929Sodium CyanideHCID 21224820HCID 21224820, compoundHCID 21226129Dichloromethane methanol

Product 1

HCID 21224836HCID 21224836, compound

Reagents, catalysts & solvents 1

HCID 160959Manganese oxideCatalyst

Procedure

A solution of 1 g of the product of Example 11 is introduced into a methylene chloride/methanol mixture (50 ml/100 ml), then 5 g of manganese oxide, 500 mg of sodium cyanide and 200 μl of acetic acid are successively added. Agitation is then maintained for 72 hours at ambient temperature.

Sources & evidence

ORD record
ord-7505a7fa21e4463cb678433db80d12a3
Source dataset
uspto-grants-1999_08
Patent number
US05932741

Reaction notes

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