反应详情

5 g (19.6 mmol) of methyl 3,3-diphenyl-2,3-epoxypropionate and 5.6 g (60 mmol) of phenol were heated together at 100° C. for 6 h. Removal of the excess phenol by distillation under high vacuum and purification of the residue by chromatography on silica gel with hexane/ethyl acetate mixtures resulted in 4.9 g (77%) of a pale yellow oil.

1. customRemoval of the excess phenol
2. distillationby distillation
3. customunder high vacuum and purification of the residue by chromatography on silica gel with hexane/ethyl acetate