HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 70135263, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | Glycine, N,N-bis(phenylMethyl)-, phenylMethyl ester | HCID 4683020 | — |
| Reactant | HCID 178418336 | HCID 178418336 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | HCID 70135263 | HCID 70135263 | — |
Reaction Steps
The title compound was prepared from N,N-dibenzyl-glycine benzyl ester, 113 mmole, and 6.5 mL, 125 mmole of acetonitrile. Following the procedure described in Example 2 the ester and nitrile mixture was added to 9.8 g, 225 mmole of sodium amide in MTBE. After solvent removal, benzyl magnesium chloride (PhCH2MgCl 250 mmole) was added following the procedure in Example 2. The resulting enamine was purified by chromatography, following the procedure described in Example 4. The yield of enamine was 41 g (102 mmole, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05932766 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-b2d69c283a9c495b820e3751dcd5cc62 |
| Source note | uspto-grants-1999_08 |