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HRID1584680

反应详情

EQUATION

反应方程式

HRID 1584680 的结构方程式

REACTANTS

反应物

3
结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：CC(C)C[C@H](NC1CCCCC([C@@H]2O[C@H](COC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)C1)C(=O)OC(C)(C)C
HCID53762226

未命名化合物

结构：CC(C)C[C@H](N)C(=O)OC(C)(C)C.Cl.Cl
HCID86754378

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)C[C@H](NC1CCCCC([C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)C1)C(=O)O
HCID54317719

未命名化合物

收率 78%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Step B--Synthesis of Nα-(3-(2,3,4,6-Tetra-O-benzoyl-β-D-galactopyranosyl)cyclohept-1-yl)-L-leucine tert-Butyl Ester: To the product from Step A (50 mg, 71 μmol) and L-leucine tert-butyl ester dihydrochloride (80 mg, 354 μmol) in dichloromethane (700 μL) and methanol 700 μL) was added sodium cyanoborohydride (2 mg). After 48 h, the mixture was concentrated and purified by column chromatography (SiO2, toluene/ethyl acetate, 8:1) to give the title compound (48 mg, 78%).

WORKUP

后处理

  1. concentrationthe mixture was concentrated
  2. custompurified by column chromatography (SiO2, toluene/ethyl acetate, 8:1)