p-Toluenesulfonic acid → HCID 21220547, compound

Participants

Reaction Steps

Methyl 5,6,7,8-tetrahydro-8-oxoisoquinolin-7-acetate (1.0 g), 4-trifluoromethyl-phenylhydrazine (1.6 g) and para-toluenesulphonic acid (0.25 g) were heated under reflux in xylene (20 ml) for 4 hours. The cooled reaction was poured into 2M sodium hydroxide solution and extracted with ethyl acetate, which was then washed with brine, dried, and evaporated to a gum. The gum was chromatographed on silica gel, eluting with ethyl acetate-isohexane (1:1), to afford a solid which was crystallised from isopropanol-isohexane to yield the title compound (0.25 g),

Provenance & Evidence