HCID 53767523, compound → HCID 18545069, compound

HRID 1584761Notes

Reaction equation

HRID 1584761 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:28])[CH:15]([NH:20]C(=O)OC(C)(C)C)[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.FC1C=CC(N2CCN(C(=O)C(NC(=O)OC(C)(C)C)CC3C=CC=CC=3)CC2)=CC=1>>[ClH:1].[NH2:20][CH:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:14]([N:11]1[CH2:10][CH2:9][N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH2:13][CH2:12]1)=[O:28]

Participants

3

Reactant 2

HCID 53767523HCID 53767523, compoundHCID 538047351,1-Dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate

Product 1

HCID 18545069HCID 18545069, compoundYield 65.7%

Procedure

Using 1,1-dimethylethyl 2-(4-(3-chlorophenyl)-1-piperazinyl)-2-oxo-1-(2-methylpropyl)ethylcarbamate in lieu of 1,1-dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate, the procedure of Reference Example 13 was otherwise repeated to provide 1-(2-amino-4-methyl-1-oxopentyl)-4-(3-chlorophenyl)piperazine hydrochloride (1.40 g, 65.7%) as white crystals.

Sources & evidence

ORD record
ord-e7e573a43fa04c3583defec2e31bb29d
Source dataset
uspto-grants-1999_08
Patent number
US05935959

Reaction notes

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