反应详情

A mixture of 4-bromo-2-methylphenol (5 g), bromoacetaldehyde dimethyl acetal (3.8 ml) and potassium hydroxide (3.0 g) in dimethylsulphoxide (15 ml) was heated to reflux for 21/2 h. Water (50 ml) was added to the cooled mixture which was then extracted with ether (4×50 ml). The extracts were washed with 5N sodium hydroxide (50 ml) and brine (50 ml), dried (MgSO4), then evaporated in vacuo to give the title compound as a brown oil (6 g).

1. temperaturewas heated
2. temperatureto reflux for 21/2 h
3. extractionwas then extracted with ether (4×50 ml)
4. washThe extracts were washed with 5N sodium hydroxide (50 ml) and brine (50 ml)
5. dry with materialdried (MgSO4)
6. customevaporated in vacuo