HCID 21220956, compound → HCID 21220907, compound

Participants

Reaction Steps

A solution of 1-(7-[1,3]dioxan-2-yl-benzofuran-5-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole (180 mg) in potassium hydroxide (0.1 g), water (10 ml) and methanol (10 ml) was stirred for 18 h at room temperature. The solvent was removed, diluted with water (10 ml) and extracted with dichloromethane (3×15 ml). The organic extracts were washed with water (10 ml), dried, and evaporated. The residual oil was dissolved in hydrochloric acid (2M; 10 ml) and tetrahydrofuran (10 ml) and stirred at 70° for 30 min. The solution was cooled, basified with 1M sodium carbonate solution and extracted with dichloromethane (3×20 ml). The combined extracts were dried, and evaporated to give the title compound as a pale cream coloured solid (74 mg).

Provenance & Evidence