5-(Tributylstannyl)pyrimidine → HCID 70107739, compound

HRID 1584786Notes

Reaction equation

HRID 1584786 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([N:14]([CH2:22][C:23]2[C:31]3[O:30][CH:29]=[CH:28][C:27]=3[CH:26]=[C:25](Br)[CH:24]=2)[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@@H:9]1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([Sn](CCCC)(CCCC)[C:44]1[CH:45]=[N:46][CH:47]=[N:48][CH:49]=1)CCC>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([N:14]([CH2:22][C:23]2[C:31]3[O:30][CH:29]=[CH:28][C:27]=3[CH:26]=[C:25]([C:44]3[CH:45]=[N:46][CH:47]=[N:48][CH:49]=3)[CH:24]=2)[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@@H:9]1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27632495-(Tributylstannyl)pyrimidineHCID 70107045HCID 70107045, compound

Product 1

HCID 70107739HCID 70107739, compound

Procedure

From cis-3-[(5-bromobenzofuran-7-ylmethyl)tert-butoxycarbonyl-amino]-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester (600 mg) and 5-tributylstannanyl-pyrimidine (458 mg)

Sources & evidence

ORD record
ord-2272c8596c1041f1aeb4de44787687d6
Source dataset
uspto-grants-1999_08
Patent number
US05935972

Reaction notes

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