Acetic Acid → N-(3-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamide

HRID 15848Notes

Reaction equation

HRID 15848 reaction equation
[CH3:1][CH:2]([C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=1)[NH2:24])[CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[CH:12]=[CH:13][C:14]([CH3:20])=[N:15]3)[CH2:6][CH2:5]1.[C:28](O)(=[O:30])[CH3:29]>>[CH3:1][CH:2]([C:21]1[CH:22]=[C:23]([NH:24][C:28](=[O:30])[CH3:29])[CH:25]=[CH:26][CH:27]=1)[CH2:3][N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[CH:12]=[CH:13][C:14]([CH3:20])=[N:15]3)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 574443353-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

Product 1

HCID 57444333N-(3-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamideYield 75%

Procedure

The title compound was prepared in 75% yield according to the general procedure for the preparation of amides (Method C) starting from 3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D21) and acetic acid.

Sources & evidence

ORD record
ord-f58e37a0e682486baf7f5ec35204eddc
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Reaction notes

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