1-(Tributylstannyl)methanol → HCID 21220903, compound

Participants

Reaction Steps

A mixture of 5-bromo-benzofuran-7-carbaldehyde (2.02 g), hydroxymethyltributyltin (4.29 g) and tetrakis(triphenylphosphine palladium (O) (1.03 g) in dry 1,4-dioxan (8 ml) was heated at reflux for 18 h. A further portion of catalyst (203 mg) was added and heating continued for 4 h. The reaction mixture was allowed to cool, and the solution was purified by FCC eluted with hexane:ethyl acetate (1:1) to give the title compound as yellow oil (0.95 g).

Provenance & Evidence