Ethyl trifluoroacetate → HCID 21220227, compound

HRID 1584820Notes

Reaction equation

HRID 1584820 reaction equation
[NH2:1][C:2]1([C:5]2[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:6]=2[CH2:12][OH:13])[CH2:4][CH2:3]1.[F:14][C:15]([F:22])([F:21])[C:16](OCC)=[O:17]>CO>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:2]2([NH:1][C:16](=[O:17])[C:15]([F:22])([F:21])[F:14])[CH2:4][CH2:3]2)=[C:6]([CH2:12][OH:13])[CH:7]=1

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 21220265HCID 21220265, compound

Product 1

HCID 21220227HCID 21220227, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 850 mg of 1-(1-aminocyclopropyl)-4-bromo-2-hydroxymethylbenzene and 8.5 ml of methanol was added 1.24 g of ethyl trifluoroacetate, and the resulting mixture was stirred at room temperature for 24 hours. The solvent was removed by distillation under reduced pressure, and the residue obtained was purified by a column chromatography (eluent: chloroform:ethanol=30:1), to obtain 1.02 g of colorless, crystalline 4-bromo-2-hydroxymethyl-1-(1-trifluoroacetylaminocyclopropyl)benzene.

Workup

  1. customThe solvent was removed by distillation under reduced pressure
  2. customthe residue obtained
  3. customwas purified by a column chromatography (eluent: chloroform:ethanol=30:1)

Sources & evidence

ORD record
ord-a96c740d1895402a9d18715f7b85de3e
Source dataset
uspto-grants-1999_08
Patent number
US05935952

Reaction notes

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