HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Product | Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate | HCID 4685753 | 98% |
Reaction Steps
A solution of ethyl 4,4,4-trifluoroacetoacetate (46 g, 0.25 mol) triethyl orthoformate (74 g, 0.50 mol) and Ac2O (77 g, 0.75 mol) was heated at 120-140° C. for 7 h. The mixture was concentrated and distilled to give the title compound in a 98% yield (58.6 g); b.p. 80-90° C., 1.5 mm/Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05935966 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-8ffdd7ee68e846c8bcbc915532cc2002 |
| Source note | uspto-grants-1999_08 |