Hydrochloric Acid → HCID 178524777, compound

Participants

Reaction Steps

A solution of ethyl 2-hydroxy-4-pentafluoroethylpyrimidine-5-carboxylate (4.0 g, 13 mmol) and NaOH (1.60 g, 39 mmol) in EtOH (20 mL) and H2O (45 mL) was heated at reflux for 1 h. The solution was cooled and acidified (concentrated HCl). The resulting solid was filtered and dried to provide 2-hydroxy-4-pentafluoroethylpyrimidine-5-carboxylic acid (3.3 g, 98% yield); 1H NMR (DMSO-d6) δ 9.90 (bs, 1H), 8.43 (s, 1H).

Provenance & Evidence