HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminomethyl)piperidine → 4-bromo-2-[N-(4-piperidylmethyl)iminomethyl]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminomethyl)piperidine | HCID 23527 | — |
| Reactant | 5-Bromosalicylaldehyde | HCID 72863 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-bromo-2-[N-(4-piperidylmethyl)iminomethyl]phenol | HCID 135450777 | 106.2% |
Reaction Steps
A mixture of 5-bromo-2-hydroxybenzaldehyde (170 g) and 4-(aminomethyl)piperidine (96.9 g) in ethanol (2.5 L) was stirred at ambient temperature for 3 hours. The solvent was removed in vacuo to give 4-bromo-2-[N-(4-piperidylmethyl)iminomethyl]phenol (267 g) as a yellow solid m.p 35-38° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05935973 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-b36ecda2af7d4a1a892ac9f922dcf031 |
| Source note | uspto-grants-1999_08 |