1-Boc-4-(aminomethyl)piperidine → HCID 54407470, compound

Participants

Reaction Steps

A solution of 2H-thieno[3,2-d][1,3]oxazine-2,4(1H)-dione (3.1 g) and 4-(aminomethyl)-1-tert-butoxycarbonylpiperidine (3.9 g) in 1,2-dimethoxyethane (50 ml) was stirred at ambient temperature for 5 hours. The solvent was removed in vacuo and the residue purified by flash chromatography over silica eluting with ether. Appropriate fractions were combined and the solvent evaporated to give 3-amino-N-(1-tert-butoxycarbonyl-4-piperidylmethyl)thiophene-2-carboxamide as a colourless solid (2.57 g).

Provenance & Evidence