2-Chloro-5-(chloromethyl)pyridine → N-((2-Chlorothiazol-5-yl)methyl)ethanamine

HRID 1585021Notes

Reaction equation

HRID 1585021 reaction equation
[Cl:1][C:2]1[S:3][C:4]([CH2:7]Cl)=[CH:5][N:6]=1.ClC1[N:15]=[CH:14][C:13](CCl)=CC=1>C(Cl)Cl>[Cl:1][C:2]1[S:3][C:4]([CH2:7][NH:15][CH2:14][CH3:13])=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 27631792-Chloro-5-chloromethylthiazole

Product 1

HCID 22450338N-((2-Chlorothiazol-5-yl)methyl)ethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction procedure of Reference Example 17 as repeated except that crude 2-chloro-5-chloromethylthiazole was used in lieu of 6-chloro-3-pyridylmethyl chloride and that CH2Cl2 was used as the extractant. The procedure gave the title compound as a crude oil.

Workup

  1. customThe reaction procedure of Reference Example 17

Sources & evidence

ORD record
ord-53c6052486d4417da1ef320f08c79f9f
Source dataset
uspto-grants-1999_08
Patent number
US05935981

Reaction notes

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