3-Pyridinemethanamine → HCID 57779898, compound

HRID 1585025Notes

Reaction equation

HRID 1585025 reaction equation
CS[C:3]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[CH:4][N+:5]([O-:7])=[O:6].[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][NH2:21])[CH:15]=1>CCO>[N:8]1([C:3]([NH:21][CH2:20][C:16]2[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=2)=[CH:4][N+:5]([O-:7])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 310183-PyridinemethanamineHCID 53823551HCID 53823551, compound

Product 1

HCID 57779898HCID 57779898, compoundYield 28.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 20 ml of EtOH was dissolved 0.8 g (0.004 mole) of 1-methylthio-1-piperidino-2-nitroethylene followed by addition of 0.4 g (0.004 mole) of 3-pyridylmethylamine. The mixture was refluxed for 2 hours. The ethanol was distilled off and the residue was purified by silica gel column chromatography to give 0.3 g of the title compound as a pale yellow powder.

Workup

  1. temperatureThe mixture was refluxed for 2 hours
  2. distillationThe ethanol was distilled off
  3. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-1fb273fa10424701a1097c140283d966
Source dataset
uspto-grants-1999_08
Patent number
US05935981

Reaction notes

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