HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Bis(methylthio)-2-nitroethylene → 1-(6-Chloro-3-pyridylmethyl)amino-1-methylthio-2-nitroethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| Reactant | 5-(Aminomethyl)-2-chloropyridine | HCID 7020927 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(6-Chloro-3-pyridylmethyl)amino-1-methylthio-2-nitroethylene | HCID 85592932 | 47.1% |
Reaction Steps
To 100 ml of EtOH were added 2.4 g (1.5×10-2 mole) of 1, 1-bis(methylthio)-2-nitroethylene and 1.4 g (9.8×10-3 mole) of 6-chloro-3-pyridylmethylamine and the mixture was refluxed for 2 hours. The EtOH was distilled off and the residue was subjected to silica gel column chromatography using CH2Cl2 as an eluent. The procedure gave 1.2 g of the title compound as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05935981 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-e4fa97a00399419ab3f3f486871d2ed0 |
| Source note | uspto-grants-1999_08 |