Trifluoroacetic acid → HCID 19361479, compound

Participants

Reaction Conditions

Reaction Steps

In 100 ml of tetrahydrofuran was dissolved 4.0 g of N-(4-carboxyphenyl)-N'-hydroxyguanidine produced in Reference Example 27. To the solution was added, while stirring at 0° C., 6.75 g of anhydrous trifluoroacetic acid. The mixture was stirred for 1.5 hour under the same conditions, followed by concentration under reduced pressure. To the concentrate was added water. The resulting crystalline product was collected by filtration, which was recrystallized from ethyl acetate--hexane to afford 3.5 g of the title compound as a colorless crystalline product.

Provenance & Evidence