Sodium Bicarbonate → HCID 131721333, compound

Participants

Reaction Steps

A solution of methyl 2-(N-BOC,N-methylamino)-4-nitrophenyl-2,3,4-tri-O-acetyl-β-D-glucuronate (5) (3 g, 5.13 mmol) in 2.12 M hydrochloric acid in ethyl acetate (60 ml) was stirred at room temperature for 1 hour. The solution was added to excess, aqueous, saturated sodium bicarbonate solution and the mixture was extracted with ethyl acetate. The organic phase was dried with sodium sulfate and concentrated. The product was chromatographed on silica gel (eluent dichloromethane/methanol 97.5/2.5). Yield 2.14 g (86%), yellow solid.

Provenance & Evidence