Hydrazine hydrate (1:1) → HCID 15662659, compound

Participants

Reaction Steps

(E)-methyl 2-[phthalimidooxymethylphenyl]-3-methoxypropenoate (1.11 g, 3.02 mmol) (prepared as described in Example 4 of EP 0463488) was suspended in methanol (25 ml) at room temperature and hydrazine hydrate (0.151 g, 3.02 mmol) was added. The resulting solution was stirred for 3 hours. The white precipitate which formed was filtered off and the solvent removed to give a white semi-solid. This was diluted with diethyl ether, and the white solid filtered off to give (E)-methyl 2-[2-aminooxymethylphenyl]-3 -methoxypropenoate (93%) as a yellow oil which was used immediately in the next stage without further purification.

Provenance & Evidence