4-Hydroxy-3,5-bis(isopropyl)benzaldehyde → HCID 9905645, compound

Participants

Reaction Steps

A mixture of 500 mg of 3,5-diisopropyl-4-hydroxybenzaldehyde and 700 mg of sulphonyl diacetonitrile in 6 ml of ethanol was refluxed with a few drops of piperidine for 4 hours. Ethanol was removed in a rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide 50 mg of the titled compound along with 30 mg of (E,E)-2-[[1-Cyano-2-(3,5diisopropyl-4-hydroxyphenyl)ethenyl]sulfonyl]-3,5-diisopropyl-4-hydroxyphenyl)acrylonitrile.

Provenance & Evidence