Trityl chloride → HCID 10374484, compound

Participants

Reaction Steps

A mixture of 1,2-diamino-2-methylpropane (XXVI, 10 ml) and triethylamine (20 ml) in methylene chloride (400 ml) is cooled to -40°. Trityl chloride (26 g) in methylene chloride (75 ml) is added dropwise and the reaction is allowed to warm to 20-25° and stir for 40 h. After a standard basic workup (methylene chloride, sodium bicarbonate and magnesium sulfate) the residue is chromatographed (silica gel; ethyl acetate/methanol, 9/1), to provide the desired compound, mp 97-98°; IR (mineral oil) 2956, 2925, 2869, 2855, 1487, 1462, 1449, 747 and 708 cm-1 ; NMR (CDCl3) 7.51, 7.27, 7.17, 1.94-2.01, 1.71-1.82 and 1.12 δ; MS (m/e) 273, 258, 243, 165 and 58.

Provenance & Evidence