反应详情

To 2-hydroxyquinoline-4-carboxylic acid (V, 5.52 g) is added a saturated methanol/hydrochloric acid mixture in 50 ml aliquots over 5 days. The methanol/hydrochloric acid is then removed under reduced pressure and the residue is carefully treated with aqueous sodium bicarbonate. When the aqueous layer tests basic, the solid is collected, washed with water, and dried under reduced pressure to give methyl 2-hydroxyquinoline-4-carboxylate (VI), mp 240-241°.

1. customThe methanol/hydrochloric acid is then removed under reduced pressure
2. additionthe residue is carefully treated with aqueous sodium bicarbonate
3. customWhen the aqueous layer tests basic, the solid is collected
4. washwashed with water
5. customdried under reduced pressure