Benzoyl chloride → HCID 14435469, compound

Participants

Reaction Conditions

Reaction Steps

In 400 ml of tetrahydrofuran, 42.0 g of 3-phenyl indole was solved. The solution and 25.0 g of potassium tert-butoxide added thereto at -30--20° C. were together heated to normal room temperature and stirred for 30 minutes. The reaction solution was cooled to -20--10° C. and 26 ml of benzoyl chloride added thereto were together heated to normal room temperature and stirred for one hour. The resultant mixture was poured into ice water and extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, distilled to expel the chloroform, crystallized by addition of isopropyl ether, separated by filtration, and dried to obtain 60.0 g of 1-benzoyl-3-phenylindole (92.8%) having a melting point of 154-156° C.

Provenance & Evidence