Nicotinoyl chloride → HCID 15428718, compound

HRID 1585216Notes

Reaction equation

HRID 1585216 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18].[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:19](=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1)[CH:6]=[C:5]2[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 82604Nicotinoyl chlorideHCID 15428717HCID 15428717, compound

Product 1

HCID 15428718HCID 15428718, compoundYield 66%

Procedure

By following the procedure of Example 1 substantially faithfully while using 10.0 g of 5-fluoro-3-(2-methoxyphenyl)indole in the place of 3-phenylindole and using nicotinoyl chloride in the place of benzoyl chloride, 9.5 g of 5-fluoro-3-(2-methoxyphenyl)-1-nicotinoylindole (66.0%) was obtained.

Sources & evidence

ORD record
ord-cae186d25e96489ba5ab0bfd1a95e395
Source dataset
uspto-grants-1999_08
Patent number
US05936098

Reaction notes

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