Sulfuric Acid → Naproxen

Participants

Reaction Conditions

Reaction Steps

A total of 6029.3 gm of an aqueous solution of sodium naproxen, prepared in accordance with the procedure of Example 1 and having 19.05 wt % sodium naproxen and a S(+)-isomer chiral purity of 97.81%, is heated to and maintained at 92° C. To this solution, 665.73 gm of dilute (30.88 wt %) sulfuric acid was fed continuously over 95 minutes. The resulting slurry was aged at 89° C. for 30 minutes and cooled to 80° C. in 30 minutes. The product was isolated using a basket centrifuge, washed with 5837 gm of hot (80° C.) water, and dried under vacuum in an oven at 90° C. A total of 993.84 gm of dry free acid naproxen final product was obtained and determined to have a chiral purity of 99.03% in the S(+)-isomer form.

Provenance & Evidence