HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1585285Generated: October 26, 2026
Sulfuric Acid → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid hydrogen sulphate
https://huagongshe.com/reaction/1585285
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | SR142948A | HCID 5311451 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid hydrogen sulphate | HCID 70246179 | 94.5% |
Reaction Steps
0.5 g of the compound obtained in EXAMPLE 1' is added to a solution of 0.08 g of H2SO4 in 5 ml of MeOH, this solution is poured into 150 ml of ether cooled to 5° C., and the precipitate formed is drained. 0.54 g of the expected product is obtained. After recrystallization in water, m.p.=212° C. (dec.). After recrystallization in 2-isopropanol, m.p.=263° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05936123 |
|---|
| Source dataset | uspto-grants-1999_08 |
|---|
| ORD ID | ord-defd73d62a6e4c5ea281fba3ec44148c |
|---|
| Source note | uspto-grants-1999_08 |
|---|
